Overall Survival

Cirrhotic liver

Non-Cirrhotic liver

HR (95% CI)

p-Value

HR (95% CI)

p-Value

Age

0.99 (0.96-1.03)

0.867

1.00 (0.96-1.03)

0.999

Male gender

0.94 (0.40-2.02)

0.888

1.73 (0.56-5.38)

0.338

Milan

0.53 (0.22-1.28)

0.163

0.69 (0.19-2-51)

0.578

UCSF

0.42 (0.18-1.00)

0.050

0.45 (0.12-1.60)

0.219

Child-Pugh score

1.67 (0.72-3.87)

0.225

BCLC

1.40 (0.61-3.23)

0.420

AFP- serum levels^*

 1.79 (0.61-5.18)

0.282

2.28 (0.58-8.87)

0.234

Edmondson-Steiner

1.25 (0.55-2.80)

0.582

1.20 (0.42-3.43)

0.725

Tumor number

1.30 (1.08- 1.57)

0.004

2.14 (1.10-4.17)

0.025

Largest tumor

1.00 (0.99-1.01)

 0.489

1.00 (0.99-1.01)

0.225

Total tumor size^**

 2.59 (1.16- 5.80)

0.020

1.60 (0.57-4.48)

0.363

Lymphovascular invasion

1.74 (0.78-3.90)

0.17

Delta/tendencia NLR (late - baseline NLR)

Delta/tendencia PLR

Recurrence-free Survival

Cirrhotic liver

Non-Cirrhotic liver

HR (95% CI)

p-Value

HR (95% CI)

p-Value

Age

1.00 (0.97-1.03)

0.925

0.99 (0.97-1.02)

0.713

Male gender

0.80 (0.35-1.79)

0.593

0.77 (0.28-2.09)

0.622

Milan

0.39 (0.16-0.93)

0.034

0.86 (0.27-2.65)

0.795

UCSF

0.355 (0.15-0.79)

0.012

0.59 (0.20-1.71)

0.340

Child-Pugh Score

1.76 (0.78-3.94)

0.170

BCLC

1.65 (0.74-3.67)

0.213

AFP- serum levels^*

1.64 (0.57-4.67)

0.354

1.02 (0.22-4-71)

0.972

Edmondson-Steiner

1.46 (0.96-2.21)

0.073

1.56 (0.85-2.87)

0.147

Tumor number

1.22 (1.00-1.50)

0.047

0.85 (0.34-2.11)

0.739

Largest tumor

1.00 (0.99-1.01)

0.205

1.00 (0.99-1.01)

0.948

Total tumor size^**

3.01 (1.39-6.52)

0.005

1.06 (0.41-2.72)

0.888

Lymphovascular invasion

1.86 (0.86-4.03)

0.114

2.22 (0.77-6.42)

0.138