No.

Name

Age

Sex

Weight

Day

C_trough^*

C_peak^*

Glomerular filtration rate (mg/mL)

Creatinine (µmol/L)

Dose

( Intravenous administration (IV) ; Nasal administration (NS)

Temperature

ECMO

Hemodialysis

ALT (9-50)

AST (15-40)

BUN (3.6-9.5)

TBIL (3.5-20.5)

DBIL (0-8.6)

Pathogen (Kind/MIC/Clearance)

AKI

Basic disease

1

CSXI

64

M

70

0

101

71.77

Loading dose：1000 mg Q12 at 11-Feb

36.5

N

N

27

15

12.8

22.9

11

　Staphylococcus haemolyticus /2 mg/L

Hypertension

5

6.80

125

60.21

1000 Q8h IV and 250 mg Q6h NS

36.5

Y

N

26

26

10.2

21.6

9

7

23.6

47.7

169

46.17

1000 Q8h IV and 250 mg Q6h NS

36.3

Y

N

38

31

8.83

57.4

26

8

19.9

41.9

177

44.34

1000 mg Q12h IV and 250 mg Q6 h NS

36.4

Y

N

29

29

8.49

34.4

14

9

11.0

33.5

146

52.44

1000 mg Q12h IV and 250 mg Q6 h NS

36.4

Y

N

20

15

6.4

24

10

11

4.63

27.9

124

60.24

1000 mg Q12h IV and 250 mg Q6 h NS

36.3

Y

N

18

16

5.3

18.1

8

13

6.70

17.0

133

56.58

500 mg Q6 h IV and 250 mg Q6 h NS

36.5

Y

N

21

21

7.43

18.4

8

14

16.0

30.8

108

68.13

500 mg Q6 h IV and 250 mg Q6h NS

36.5

Y

N

26

27

8.76

26.2

9

15

19.7

36.6

85.6

83.1

500 mg Q6 h IV and 250 mg Q6 h NS

36.5

Y

N

29

20

10.4

24.4

10

16

10.3

18.5

93.4

77.04

500 mg Q6 h IV and 250 mg Q6 h NS

36.5

Y

N

32

21

9

25.9

11

17

11.2

19.5

75.7

92.47

500 mg Q6 h IV and 250 mg Q6 h NS

36.5

Y

N

32

52

7.71

21

6

18

9.97

17.8

109

67.28

500 mg Q6 h IV and 250 mg Q6 h NS

38.8

Y

N

29

28

6.85

16.5

6

19

10.0

25.9

127

58.87

500 mg Q6 h IV and 250 mg Q6 h NS

36.5

Y

N

22

18

9.05

25.9

12

20

14.4

30.9

143

53.38

500 mg Q6 h IV and 250 mg Q6 h NS

37

Y

N

19

16

9.67

20.2

10

22

17.2

23.8

130

57.85

500 mg Q6 h IV and 250 mg Q6 h NS

36.5

Y

N

22

18

9

21.5

10

25

17.2

23.8

106

68.91

500 mg Q6 h IV and 250 mg Q6 h NS

36.5

Y

N

12

13

11.6

26.3

12

26

93.7

76.82

500 mg Q6 h IV and 250 mg Q6 h NS, stop NS at PM

37.6

Y

N

12

22

13.6

27.2

12

28

14.9

70.3

98.63

500 mg Q6 h IV, stop IV at PM

37.8

Y

N

9

15

14.3

24.9

12

Turn negative

1

2

SGHE

81

M

70

0

31.7

188.7

Loading dose：1000 mg Q12 at 13-Feb

36.7

Y

Y

56

94

21.4

38.7

25

Enterococcus faecalis/2 mg/L　

Hypertension;

Coronary heart disease;

Renal dysfunction

3

33.0

54.3

118.4

1000 mg Q8 h IV

36.5

Y

Y

66

37

15

58.4

30

4

46.6

59.4

109.6

1000 mg Q8 h IV, stop IV at PM

36.5

Y

Y

68

31

15.3

51.5

31

5

49.9

47.2

133.7

250 mg Q6 h NS

36.5

Y

Y

67

25

15.5

67.4

42

6

34.2

95.3

72.68

250 mg Q6 h NS

36.5

Y

Y

56

38

12.7

48.6

24

7

12.5

73.3

91.25

250 mg Q6 h NS

36.5

Y

Y

45

16

10.9

54.5

30

9

11.2

57.9

112

1000 mg Q24 h IV, 250 mg Q6 h NS

36.5

Y

Y

43

21

12.9

43.2

24

10

12.3

63.1

104

1000 mg Q24 h IV, 250 mg Q6 h NS

36.5

Y

Y

39

16

8.81

35.4

20

11

10.3

24.6

93.8

73.71

1000 mg Q24 h IV, Stop at PM, 250 mg Q6 h NS

36.5

Y

Y

38

23

7.5

36.6

22

12

20.5

41.3

99.8

69.83

 250 mg Q6h NS

37.1

Y

Y

34

20

6.42

36.8

22

15

7.80

83.9

81.22

 250 mg Q6 h NS

36.5

Y

Y

50

55

5.68

45.5

24

17

6.70

113

62.83

 250 mg Q6 h NS

36.5

Y

Y

30

59

5.09

32.5

13

18

13.1

97.8

71.08

 250 mg Q6 h NS

36.5

Y

Y

27

32

4.5

32.2

18

21

10.4

33.0

83.5

81.52

 250 mg Q6 h NS

36.5

Y

Y

22

35

6.11

26.7

17

23

6.00

24.3

97.1

71.53

 250 mg Q6 h NS

36.5

Y

Y

41

34

5.64

24.4

15

27

5.90

23.6

112

63.01

 250 mg Q6 h NS

36.5

Y

Y

22

110

12.1

68.4

23

33

7.30

21.8

62.2

105.3

 250 mg Q6 h NS

36.5

Y

Y

41

55

15.5

41.5

29

39

148

49.7

250 mg Q6 h NS, stop NS

36.5

Y

Y

33

56

8.06

30.1

20

Turn negative

NA

3

TJGU

62

M

75

0

92

77.4

 1000 mg Q12 h at 12-Feb

36.6

Y

N

33

40

5.06

7.8

8

Enterococcus faecium/≤ 0.5 mg/L　

No

4

11.8

102

72.05

1000 mg Q12 h

36.7

Y

N

26

24

7.24

13

6

25

135

56.4

1000 mg Q12 h, stop drug at PM

36.8

Y

N

56

44

4.72

6.5

6

Turn Negative

NA

4

ZXHU

75

M

85

0

80.1

85.62

500 mg q8 h IV begin at 13-Feb

36.6

Y

Y

20

30

21

19.2

11

Enterococcus faecium /≤ 0.5 mg/L　

Premature beat;

Surgical history of bladder cancer

4

26.6

131

55.83

500 mg Q8 h IV

37

Y

Y

33

47

13

31.6

15

5

25.5

74.8

98.92

500 mg Q8 h IV, stop at PM

36.9

Y

Y

35

52

11.2

24.1

15

6

95.4

73.58

No drug

37

Y

Y

33

45

13.1

28.6

16

7

63.3

105

No drug

36.6

Y

N

41

69

13.4

21.6

11

8

77

88.59

No drug

36.6

Y

N

37

48

15.1

17.9

9

9

67.9

98.78

No drug

36.6

Y

Y

38

47

16.2

19.8

10

10

49.6

81.16

500 mg Q8 h IV and 250 mg Q6 h NS

37.2

Y

Y

28

35

16.2

24.5

12

12

19.5

41.7

101.4

69.79

500 mg Q8 IV and 250 mg Q6 h NS

36.9

Y

Y

31

47

11

30.7

13

15

63.8

104.3

500 mg Q8 IV, stop IV drug at PM, and 250 mg Q6h NS

36.8

Y

Y

39

32

15.5

31.5

17

17

93.3

75.05

250 mg Q6 h, stop NS drug at PM

36.8

Y

Y

44

39

12.5

36.1

13

Turn negative

3

5

ZYDI

57

F

65

0

108

46.88

Loading dose: 1000 mg Q12 IV at 23-Feb

38.7

N

N

25

17

4.35

8.4

3

Staphylococcushaemolyticus/1 mg/L

Hypertension;

Diabetes

2

12.1

41.4

142

42.74

1000 mg Q12 IV and 250 mg Q6 h NS

37.7

N

N

23

14

5.53

7.5

3

7

102

56.4

250 mg Q6 h NS, stop NS at PM

37.3

N

N

54

23

7.99

6.9

3

13

108

53.56

1000 mg Q12 h, Stop IV at PM

37.2

N

N

28

16

6.41

7.9

3

Turn negative

NA

6

XSMI

70

M

75

0

88.1

79.82

Loading dose: 1000 mg Q12h IV at 16-Feb

36

N

Y

22

22

10.2

13.4

8..8

Staphylococcushaemolyticus/ 1 mg/L

Hypertension;

Diabetes;

Hyperlipidemia

3

15.1　

93.5

75.82

1000 mg Q12 h IV

38.2

N

Y

21

26

6.81

18

8

11

109

66.26

1000 mg Q12 h, stop IV at PM

36.5

N

Y

18

22

7.43

15.8

8

Turn negative

NA　

7

YAWE

63

F

55

0

194

31.67

Loading dose: 1000 mg Q12 h IV at 17-Feb

36.9

Y

N

28

43

9.69

14.9

12

NA

Operation history of hysteromyoma

6

14.3

34.8

77.8

69.89

 1000 mg Q12 h IV, stop IV at PM, and 125q6NS

36.7

Y

N

44

36

10.9

33.7

23

11

51

100.8

125 Q6 h NS, stop NS at PM

36.5

Y

N

53

77

14.2

20.7

8

2

8

ZHBI

65

M

70

0

44.4

146.5

Loading dose: 1000 mg Q12 h IV at 8-Mar

36.6

N

Y

25

28

9.6

55.2

43

Enterococcus faecium/≤ 0.5 mg/L

Hypertension;

Diabetes

5

24.6　

43.9

148

Adjusting dose to 500 mg Q12 h IV, stop IV at PM

36.9

N

Y

18

17

10.3

25.2

19

Turn negative

NA